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10.1124/dmd.108.026088 25 GavardJ
Hormonal changes Hormonal shifts during pregnancy can prompt your body to store more fat cells than usual
A 2025 network meta-analysis put lean mass at roughly a quarter of total weight reduction for both semaglutide and tirzepatide, which is similar to what happens with any weight loss
The workaround: if you have a contraindication to step therapy medications (for example, cardiovascular disease that contraindicates phentermine, or chronic diarrhea that contraindicates orlistat), your provider can request a step therapy override
Persistent flank pain, blood in urine, or severe nausea requires prompt medical review
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