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10.1038/cddis.2014.221 56 ZhangQ.LiuJ.DengM
Biohacking wird in der einschlgigen Comminity weniger als rationales Selbstexperiment denn als Ausdruck eines Glaubens an einen beschleunigten Fortschritt und an die persnliche Ausnahmestellung demonstriert
These include (i) rational drug combinations targeting parallel or converging signaling cascades, (ii) the use of allosteric inhibitors or degraders that disrupt key signaling hubs, (iii) vertical inhibition along a single pathway to prevent upstream feedback reactivation, and (iv) the application of systems biology and network modeling to predict synthetic lethal vulnerabilities
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