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Nausea, vomiting, diarrhea, constipation, and stomach pain are the most common side effects
Large cardiovascular trials and pooled analyses have not shown a statistically higher pancreatitis incidence than placebo beyond what is expected in diabetics (who inherently have some risk)
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Unlike caloric restriction alone, which often results in both fat and muscle loss, the peptides mechanism specifically targets adipose tissue without promoting protein catabolism
The common gut symptoms are usually worst while the dose is being increased, then ease over the following weeks for most people (Moiz 2025)
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