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In fact, uncomplicated subjects are not entirely free of neuropathological alterations at the cellular level either because they show regionally selective degeneration of pyramidal neurons or their dendrites in some brain regions such as the PFC (Kril et al., 1997)

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The genetic effect was modest, much of the original dataset was self-reported, the cohort was predominantly of European ancestry, and most of the predictive information in the authors' models still came from non-genetic factors

The authors concluded that this formulation notably enhanced various skin tone parameters in middle-aged women [77]

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