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4a, b) NOX family enzymes are widely known for their role in oxidative burst utilized by neutrophils and macrophages to kill phagocytosed pathogens

~25-29% total reduction possible by 68 weeks for those who stay consistent

If these are optimized and you tolerate your current dose without significant side effects, a dose increase is reasonable and often effective

Not recommended in case of kidney, heart and cardiovascular disease, neither for people who suffer from diseases accompanied with seizures

The trial was stopped based on an interim analysis meeting pre-specified criteria for stopping the trial early for efficacy