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And, most recently, an analysis of the electronic health records of 817,309 patients with a history of AUD from January 2014 to August 2022 found that those taking GLP-1s experienced lower rates of alcohol intoxication

Results, published in September 2025 in The New England Journal of Medicine , show that high-dose oral semaglutide tablets (25 mg) led to an average weight loss of about 1417% over a little more than a year , along with additional benefits like lower blood pressure and reduced inflammation

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