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Why GLP-1 Medications Do Not Resolve Root Metabolic Dysfunction While GLP-1 agonists can improve glycemic control and suppress appetite, they do not address the underlying drivers of metabolic dysfunction

Although ectopic lipid accumulation in peripheral tissue appears to be the primary cause of insulin resistance, increased ER stress, inflammation, and reactive oxygen species levels, dysregulations of adipokines contribute to the pathogenesis of insulin resistance in liver and skeletal muscle

Similarly, sex-specific differences in neuroinflammatory and neuroregenerative responses are increasingly recognized, reinforcing the need for sex-balanced study designs [576]

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