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Another network meta-analysis of RCTs, including participants with T2DM, found that GLP-1 RAs decreased the risk of non-fatal MI (Odds Ratio [OR] = 0.92, 95%CI = 0.850.99) when compared to placebo or standard care ( Unstable angina pectoris: An umbrella review of meta-analyses of RCTs including 56,004 patients with diabetes, prediabetes, and at high risk of diabetes, found no association between GLP-1 RAs and the risk of uAP (RR = 1.06, 95%CI = 0.931.21) when compared to placebo (Zhu et al., 2020)
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rather, it means your doctor must rely on indirect biomarkers to confirm treatment is working
Contact your doctor or healthcare team if you experience: Persistent or severe nausea, vomiting, or diarrhoea affecting your ability to eat, drink, or function normally Signs of dehydration from persistent gastrointestinal losses, such as dizziness, light-headedness, or significantly reduced urination Signs of pancreatitis , including severe upper abdominal pain that may radiate to the back call 999 or go to your nearest A&E immediately if pain is severe Gallbladder symptoms such as right upper abdominal pain, fever, or yellowing of the skin or eyes (jaundice) Symptoms of hypoglycaemia (low blood sugar) particularly if you are also taking diabetes medications such as insulin or sulphonylureas
A cross-sectional report from the Oxford Aging Project found that the 80th percentile for MMA was 350 nmol/l among people age 65 years (Clarke, 2003)
