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Retatrutide's Phase 2 trial data (Jastreboff et al., NEJM 2023) identified a side-effect profile broadly consistent with other incretin-based therapies: Gastrointestinal : Nausea, vomiting, diarrhoea, and constipation were the most commonly reported adverse effects, particularly during dose escalation
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Lets go back in time to the mid 1920s when the Nobel prize for medicines recipients had received the honour for discovering that patients with Pernicious Anaemia could be kept alive by giving them raw or slightly cooked liver
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