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FIGURE 9 Summary and conclusions: Glutathione and early (premature) inflammaging Chronic inflammatory diseases especially those compromising the lower respiratory system (chronic obstructive pulmonary disease, lower respiratory infections, cystic fibrosis, idiopathic pulmonary fibrosis, acute respiratory distress syndrome), diseases compromising the cardiovascular system (atherosclerosis, ischemic heart disease, stroke, and others), many other systemic inflammatory diseases like diabetes (274, 275)

p = 0.008), but no statistically significant difference for CV mortality when PIONEER 6 was omitted

The convenience of a tablet is enormous

Prevents the development of necrosis of many tissues

Events are dose-related and often improve with titration