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One study in healthy adults with normal coagulation (blood clotting) status found that daily supplementation with 1,000 IU (670 mg) of RRR --tocopherol for 12 weeks decreased -carboxylation of prothrombin, a vitamin K-dependent factor in the coagulation cascade (127)

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Most patients are seen within 24 hours, with insurance and cash-pay options available

And high patient out-of-pocket costs owing to lack of insurance coverage continues to be a substantial obstacle, limiting initial uptake and leading to discontinuation for some who do start