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Non-pharmacologic interventions such as aerobic exercise, cognitive behavioral therapy, sleep hygiene, and nutritional support are also widely recommended, often with greater long-term benefit but requiring significant patient engagement

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concluded that Semaglutide is not associated with an increased risk of suicidal ideation in the real-world settings 38

For patients whose Crohn's severity or medication interactions contraindicate traditional semaglutide, PlexusDx's microdose GLP-1 protocol ($129/month) or dual-compound GLP-Squared options may provide gentler alternatives