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In the SURPASS-2 study, the three doses of tirzepatide (5, 10, and 15 mg once weekly) were tested with the GLP-1RA semaglutide (1 mg once weekly) as a comparator in patients not optimally controlled on monotherapy with metformin (71)

A 2020 study comparing weekly semaglutide to daily subcutaneous liraglutide showed a more significant overall weight loss in those that received semaglutide