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These side effects include diarrhea, fatigue, anxiety, constipation, fast pulse, tingling lips, dry mouth, increased hunger, incontinence, rashes, insomnia, irritability, lightheadedness and nausea

DES(1-3) IGF-1 is not separately enumerated on the WADA Prohibited List as of the 2026 iteration, although the WADA S2 category includes language covering "any substance with similar chemical structure or similar biological effect(s)," which would encompass IGF-1 analogues broadly

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In England , the National Institute of Health and Care Excellence (NICE) has approved three GLP-1 class medications for weight management in adults, to be used alongside a reduced calorie diet and increased physical activity: Liraglutide Semaglutide Tirzepatide The two most recently approved are semaglutide (available as Wegovy) and tirzepatide (available as Mounjaro/Zepbound)