glp 1 heart muscle Direct cardiovascular effects of glucagon like peptide-1 | Diabetology & Metabolic Syndrome Cardiovascular Effects of Glucagon-Like Peptide-1

In patients with Type 2 diabetes, this effect is blunted and the sugar floats around in the bloodstream much longer

doi: 10.1016/j.immuni.2025.04.002 113 Cembellin-PrietoALuoZKulagaHBaumgarthN

This leads to an imbalance in the glutathione/reactive oxygen species (ROS) axis and enhanced pyrimidine biosynthesis, which in turn sustains the cancer stem cell-like properties of lung cancer cells and drives the malignant progression of NSCLC ( Metabolites involved in the serine/glycine pathway are markedly depleted in the plasma of NSCLC patients after radiotherapy and in corresponding cellular models, indicating that tumor cells utilize these metabolites to facilitate DNA damage repair and cell survival

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Small molecules can have different storage and handling requirements than peptides