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Studies show that depression scores correlate to higher quinolinic acid in the blood, and postmortem studies show more cells in the brain producing quinolinic acid in suicide victims.[ref] Hepatitis C patients treated with interferon-alpha have depression and higher kynurenine metabolites.[ref] Another reason tryptophan metabolism could tilt more towards kynurenine is when the body is lacking in niacin
The safety and effectiveness of this compound have not been fully evaluated in clinical trials, and its long-term effects are unknown
Systemic effects include fluid retention, arthralgias, and peripheral edema consistent with GH excess
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Retatrutide produces higher rates of nausea (43% vs 20-47%), diarrhea (33% vs lower), and vomiting (21% vs lower) at their respective maintenance doses
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