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The diuretic and natriuretic effects of GLP-1 are mediated through downregulation of sodiumhydrogen exchanger 3 (NHE3) activity in the renal proximal tubule that consequently affects renal hemodynamics [112]
Yang, A
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Furthermore, progressive loss of NRF2 activity was seen with aging, which may be explained by studies showing that the expression of NRF2 positive regulators P62 and BRCA1 decreased with age, while NRF2 negative regulators, KEAP1 and BACH1, increased with age [113]
Below, across-subjects results are reported as (mean (median) SD)
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