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Additional safety concerns include hypoglycemia risk when used with insulin or insulin secretagogues, potential acute kidney injury with dehydration, and with semaglutide, worsening of diabetic retinopathy in patients with pre-existing retinopathy

Surgery Surgical intervention may be an option for neuropathy that has led to deformities of the foot and other joints, Mathur says

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Collagen and fibroblast activity: In animal studies, BPC-157 has been associated with altered fibroblast activity and collagen deposition patterns