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The growing body of evidence suggests that the effects of GLP-1 RAs extend beyond a single organ and can positively influence health across various organ systems and specific health conditions, indicating their potential use for non-obese but otherwise metabolically healthy individuals to enhance their overall well-being
It works by mimicking the action of Glucagon-like Peptide-1 (GLP-1), promoting insulin secretion, inhibiting glucagon secretion, and delaying gastric emptying, which helps control blood sugar levels and aids in weight loss
One study found that a 2% concentration of a glutathione cream improved the melanin index (a measure of melanin in skin) on dark spots when used twice a day for 10 weeks
While SGLT-2is (e.g., empagliflozin, canagliflozin) and DDP-4is (e.g., sitagliptin) are exclusively available as orally administered medications, both oral and subcutaneous formulations of the GPL-1RA semaglutide are available