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For researchers focused specifically on weight management outcomes, the full escalation to 12mg provides the most robust data, though the 8mg dose produced 22.8% weight loss, only 1.4 percentage points less

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Phase 2 Trial: Study Design and Population The landmark Phase 2 trial enrolled 338 adults with obesity (BMI 30) or overweight with comorbidities (BMI 27)

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Excision of such large tumor would be absolutely contraindicated if the lesion's identity is uncertain