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(Source: Sabatella et al., Obesity , 2026) Why the Gap Is Partly About Adherence, Not Just the Drug The most important context for these numbers is one the lead researchers themselves emphasized: much of the observed gap reflects how GLP-1 therapy is actually used in the real world, not a ceiling on what the medication can achieve
Lifestyle integration, adherence, and follow-up
Both published network meta-analyses point in the same direction
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A recent city report found that only 53% of the 718 people whom police cited for substance use over a 10-month period that ended in February said they lived in the city
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