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To test the hypothesis that a disorder of ROS homeostasis is induced by OsG-produced oxidative stress, an antioxidant, GSH (50 mg/kg/ 6 h), was subcutaneously injected into animals with LOsG challenge as described above, defined as the LOsG.TdGSH group ( n = 10)

488,489,490 In the pancreas, this stimulates the secretion of insulin and inhibits the secretion of glucagon

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For instance, in HEK293 cells, GRK2 was demonstrated to interact with the GLP-1R by BRET [47, 48] and by FRET [49]