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In regard to CRP, the elevation of CRP in patients who have periodontitis serves not only to reflect the hepatic acute phase responses, but also to predict the incidence of myocardial infarction and stroke, thus making CRP an excellent agent to be included in the stratification of risk for CVD [18, 48]

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While the exact cause of vitiligo is still unknown, researchers believe that vitiligo causes involve a combination of genetic predisposition, environmental triggers, and autoimmune factors which ultimately cause the destruction of melanocytes the cells responsible for producing melanin which give skin its color