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Another study in colonic-sensitized rat models demonstrated that exendin-4 treatment dose-dependently reduced visceral hypersensitivity by upregulating serotonin transporter (SERT) expression and downregulating tryptophan hydroxylase-1 (TPH-1) expression [57]
It was first isolated from human plasma in 1973 by Dr
10.3132/dvdr.2004.005
Journal of Positive Psychology and Wellbeing, 8 (4), 1941
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