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Impaired mitophagy permits accumulation of dysfunctional mitochondria, establishing a feed-forward cycle of oxidative stress within the supraspinatus

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The proposed mechanism doesnt have a strong circadian rationale, so timing is flexible

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On the other hand, glutathione-mimetic compounds or -glutamylcysteine (-GC), the limiting substrate for GSH biosynthesis, ameliorate brain pathologies and memory deficits in APP/PS1 63,64

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