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extrapolating it into a claim of clean human endocrine selectivity is not supported

Magnesium citrate In a study of 40 patients with migraine without aura, oral magnesium citrate (600 mg daily) decreased the frequency of attacks by 33% and severity of attacks by 47% (Koseoglu 2008)

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Employing melatonin as an immunomodulatory agent therefore may require higher dosages to be effective, for example in murine models, a dose of 10mg/kg is widely used to investigate the anti-inflammatory and tissue-protective actions of melatonin (2931, 70)