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StatPearls [Internet], StatPearls Publishing, 21 Dec

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In the case of coffee enemas, the scientific research is in stark contrast to how coffee enemas are typically advertised in the alternative health community as Unmatched Detoxification for Health and Recovery

The last I heard, about 1 in 6 Americans have tried either semaglutide or tirzepatide, so most people have a friend who's been on it and they've heard the anecdotes