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The evidence base consistently demonstrates that modest caloric restriction combined with regular exercise produces clinically significant weight loss and improves metabolic health markers

Additionally, GATA5 influences lung function 66 ,where reduced lung function has been associated with an increased risk of glaucoma 67

Practical Guidance (Interim) Clinicians should counsel that current evidence does not justify routine therapeutic use outside registered ethically approved research protocols and that online sourcing introduces quality, legal and professional risk

Bosma PJ, Goldhoon B, Bakker C

2018;26:931 Li Y, Tian H, Zeng H, Zhang Y, Yin T, He H, et al