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Le Vaillant J, et al

This can lead to an aggravation of hepatic steatosis (fatty liver), particularly in individuals with pre-existing liver damage ( Studies suggest that in some cases, the KD may induce metabolic dysregulation in liver fatty acid metabolism, causing an accumulation of triglycerides and free fatty acids within hepatocytes ( 4.2.3.2 Increased metabolic burden on the liver The KD imposes a significant metabolic burden on the liver, particularly in individuals whose liver function is already compromised ( For individuals with pre-existing liver disease or reduced hepatic function, this increased metabolic stress may lead to further liver damage

Cytosolic NADP(+)-dependent isocitrate dehydrogenase protects macrophages from LPS-induced nitric oxide and reactive oxygen species

Cystic fibrosis: Inhaled glutathione and oral NAC have been studied in cystic fibrosis, where lung glutathione is severely depleted

It is naturally produced by the body, but levels may vary due to lifestyle, environmental exposure, and metabolic demands