Brains were rapidly extracted and immersed in chilled cutting solution (250 mM sucrose, 26 mM NaHCO 3 , 10 mM D(+)-glucose, 4 mM MgCl 2 , 3 mM myo-inositol, 2.5 mM KCl, 2 mM sodium pyruvate, 1.25 mM NaH 2 PO 4 , 0.5 mM ascorbic acid, 0.1 mM CaCl 2 , and 1 mM kynurenic acid, pH 7.4, continuously oxygenated with 95% O 2 and 5% CO 2 )
Non-GLP-1 medications for diabetes and obesity, such as metformin or orlistat, could be options
This is all kind of speculation
Second, it is the obligatory substrate for sirtuins, a family of longevity-related proteins that regulate inflammation, metabolic health and DNA stability
The utilization of glucagon-like peptide 1 agonists and risk of following external eye diseases in type 2 diabetes mellitus individuals: a population-based study