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Pathological causes of elevated B12 warrant careful consideration: Haematological disorders : Myeloproliferative neoplasms (polycythaemia vera, chronic myeloid leukaemia), acute leukaemia, and lymphoproliferative disorders can increase B12-binding proteins (transcobalamin and haptocorrin), elevating total serum B12 [3] Liver disease : Hepatocellular damage releases stored B12 into circulation
Phase 3: Maintenance (Weeks 912) Dose: 2-3x per week Pulsed administration keeps the repair signal present without turning the protocol into constant stimulation
The two are structurally unrelated and act through different biological pathways, which is the main reason researchers became interested in studying them in combination
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