Multiple variants in GLP1R have been found to affect how well the receptor responds which is why clinical trials of GLP-1 drugs show some patients lose dramatically more weight than others on the exact same medication
Lancet Diabetes Endocrinol 7(10):776785 Vilsbll T, Christensen M, Junker AE, Knop FK, Gluud LL (2012) Effects of glucagon-like peptide-1 receptor agonists on weight loss: systematic review and meta-analyses of randomised controlled trials
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(Folate deficiency disrupts normal DNA synthesis and methylation, which interferes with cell division and development, especially in rapidly dividing embryos.) Megaloblastic anemia, which can lead to symptoms like fatigue, weakness, and difficulty concentrating Elevated homocysteine, even when B12 levels are normal
Mainstream media appears to mirror this trend as nearly every other radio and television ad seemingly involves a weight loss medication