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doi: 10.1056/NEJMoa1600869 Drucker DJ

Inhibition of arginase by CB-1158 blocks myeloid cell-mediated immune suppression in the tumor microenvironment

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Activation of FXR enhances the expression of tight junction-associated proteins such as occludin, claudin-1, and zonula occludens-1 (ZO-1), thereby reducing paracellular permeability and reinforcing epithelial resistance to luminal antigens and pathogens (65)