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What the evidence does not establish: there is no Phase 3 evidence supporting PT-141 use in men, in postmenopausal women, or via the intranasal route for any indication

[8] [9] Low-energy diets (800-1,200 kcal) may be appropriate for some individuals but should be nutritionally complete and medically supervised

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Esazadeh et al., 2024), while other authors claim that it is generally safe (Shaw, 2018)