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All 12 patients scored a 5/5 on the Global Response Assessment, so this therapy was considered successful

These models allow scientists to examine enzymatic pathway modulation in controlled laboratory environments

For quantification of sulfur-containing metabolites in cultured cancer cells and mouse serum, 10 l samples were extracted with 90 l of ice-cold extraction solvent (80% methanol and 20% H 2 O) containing isotope-labelled internal standards (36 M 13 C 2 15 N-GSH, 0.92 M 13 C 4 15 N 2 -GSSG and 10 M D 4 -cystine)

Importantly, serum BDNF reflects platelet release during clotting rather than direct brain levels, so its clinical utility as a biomarker remains debated

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