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Theoretical and Class-Level Risks These have not been confirmed in cagrilintide trials but are flagged because they appear in related amylin or GLP-1 class data: pancreatitis, gallbladder disease, severe hypoglycemia (mainly when combined with insulin or sulfonylureas), and acute kidney injury secondary to dehydration from severe nausea or vomiting

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Given that we also demonstrated that X(PC) cleaves multiple downstream caspase substrates, this partial reduction could result from engagement of alternate caspase-mediated pathways or off-target cleavage of other protease-sensitive death effectors

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