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Evidence for differential catalytic activity of the encoded proteins

These compounds are not intended to diagnose, treat, cure, or prevent any disease

These results suggest that pathways other than Wnt signaling may be responsible for initiating the regenerative response of supporting cells after hair cell loss but that active Wnt signaling is both necessary and sufficient for proliferation in later stages of hair cell regeneration

Strategies to minimize immunogenicity include careful peptide design to maintain similarity to natural sequences, appropriate formulation development, and monitoring for antibody formation during clinical development and post-market surveillance