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According to the Summary of Product Characteristics (SmPC), these include: Nausea (very common: may affect more than 1 in 10 people) Diarrhoea and constipation (very common) Vomiting and abdominal pain (very common) Decreased appetite and dyspepsia (very common) Most gastrointestinal adverse effects are mild to moderate in severity and tend to diminish over time as the body adjusts to treatment

Clear, colorless solution indicates successful reconstitution

Dose escalation : Physicians typically begin with a low dose and titrate slowly

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Presently, the primary FDA-approved indication of oral isotretinoin is severe recalcitrant nodular acne. In simple terms, that means the persistence of many inflamed pimples at least 5 mm in size despite conventional treatment