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Additionally, it is important to speak with a healthcare provider before starting a supplementation regimen, as taking too much vitamin D can lead to harmful side effects such as nausea, weakness, and kidney damage
Toxicology 228 , 98108 (2006)
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6 Coincidentally, downregulated Sirtuin 3 (Sirt3)-mediated hyperacetylation of PDHA1 promotes the lactylation of mitochondrial fission 1 protein (Fis1) at K20 by increasing lactate overproduction in renal tubular epithelial cells, resulting in excessive mitochondrial injury
