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As an optimized version of 2-BP, cyano-myracrylamide (CMA) is less readily converted to the CoA form and is less cytotoxic, and thus it is a potent alternative to 2-BP [170, 171]
In December 2025, the administration also introduced the BALANCE (Better Approaches to Lifestyle and Nutrition for Comprehensive hEalth) model, a five year CMS Innovation Center (CMMI) model that intends to expand access to obesity drugs in Medicaid and Medicare by negotiating lower GLP-1 prices with manufacturers
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