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Although the relevance of these mechanisms in MMNST remains to be fully elucidated, we hypothesize that, in this case, anlotinib contributed to durable disease control not only through its established antiangiogenic and antiproliferative actions but also by promoting vascular normalization, reshaping the immune microenvironment, and potentially modulating the PRKAR1A/ERK axis
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Additionally, hormonal changes occur during weight loss, including alterations in leptin, ghrelin, and other appetite-regulating hormones
mRNA detection and quantitation The procedure for in situ hybridization was adapted from Jones et al
Clinical practice update on GI side effects of GLP-1 receptor agonists
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