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Neither conclusion can be applied to humans at typical compounded doses (250 to 500 mcg subcutaneously) because: Rodent doses (10 mcg/kg intraperitoneally) do not translate linearly to human subcutaneous pharmacokinetics
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For those willing to accept this level of uncertainty, the risk-benefit calculation may still favor trying BPC-157, especially given its favorable safety profile and the limited options for chronic back pain sufferers
While severe complications are uncommon, patients should contact their prescribing provider if they believe they have taken an incorrect dose
Inhibiting the enzyme pharmacologically aims to reproduce that effect, which is why multiple independent NNMT inhibitors have been developed
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