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Rapid weight reduction often results in loss of both fat and lean tissue, potentially compromising metabolic health and physical function

It is postulated that DM-induced oxidative damage may be more significant in erythrocytes than in other cells, due to their high content of iron and polyunsaturated fatty acids, as well as their role as oxygen transporters, with a high degree of exposure to free radicals [320]

Cureus 15, e43773

When fat cells shrink, they release hormones differently, and this can lead to lighter, heavier, shorter, or longer periods

Clinical trial data consistently demonstrates that injectable GLP-1 receptor agonists produce greater average weight loss than currently available licensed oral options in the UK, though individual responses vary considerably