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2004), albeit at higher concentrations than primary cells (Raza and John 2015), they do so via caspase-mediated apoptosis, not necrosis (Jaeschke et al
Current applications focus primarily on musculoskeletal conditions including tendon and ligament injuries, muscle strains, and wound healing
Several other studies, including evaluations of the selective PDE10A inhibitor Lu AF11167 and the PDE1B inhibitor ITI-214, also exhibited suboptimal efficacy in clinical studies (Li et al., 2016
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Some claim that it is good, while others question its safety, particularly for skin whitening
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