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FIGURE 2 4.4.2 Hepatic antifibrotic mechanisms Liver fibrosis, a prevalent consequence of chronic liver conditions including hepatitis B or C, alcohol-related liver damage, and non-alcoholic fatty liver disease, can escalate to cirrhosisa severe and often irreversible state if not addressed

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Yousefzadeh MJ, Zhu Y, McGowan SJ, Angelini L, Fuhrmann-Stroissnigg H, Xu M, Ling YY, Melos KI, Pirtskhalava T, Inman CL, McGuckian C, Wade EA, Kato JI, Grassi D, Wentworth M, Burd CE, Arriaga EA, Ladiges WL, Tchkonia T, Kirkland JL, Robbins PD, Niedernhofer LJ