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The classification also does not take into account heterozygosity, which results in a wider spread of residual enzyme activity, as well as the effect of compounding mutations which has been shown to synergistically decrease the catalytic activity and/or protein stability (34)

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2.2 Somatostatin (SS) At the end of the 1960s, McCanns group observed that bovine hypothalamic extracts were able to inhibit the release of GH from pituitary cultures