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Is it normal for a vacuum to be present in the lyophilized peptide vial

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Source: Oxford Academic Additional studies have been conducted in rabbit joint models of osteoarthritis (OA) using experimental intra-articular doses of AOD9604 (with or without hyaluronic acid), investigating cartilage and matrix biology in controlled preclinical systems

If needed, sonication (brief exposure to ultrasonic waves) can help dissolve stubborn peptides