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Beneficial effects of GLP-1 in reducing toxic protein accumulation are hypothesized to occur through the PI3K/Akt inactivation of glycogen synthase kinase 3 beta (GSK3) [82] and a possible GLP-1 mediated upregulation of IDE [83]

How Retatrutide Works: The Triple Agonist Explained To understand why retatrutide is getting so much attention, it helps to understand what "triple agonist" actually means in practical terms

Fang et al (103) demonstrated that recombinant human GLP-1 improved neurological deficits and reduced infarct volume in rats with middle cerebral artery occlusion by inhibiting oxidative stress and apoptosis, and promoting excitatory amino acid transporter-2 expression

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