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The column was then washed with 10 CV of 25 mM imidazole (Sigma-Aldrich) in DPBS (pH 7.2), followed by elution with 10 CV of 250 mM imidazole in DPBS (pH 7.3)

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In vitro, LY3437943 demonstrates a well-balanced activity between GCGR and GLP-1R, but more activity towards GIPR

However, the competitive landscape is expected to broaden as next-generation therapies reach the market