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This canonical GHRH pathway stimulates somatotroph proliferation, GH mRNA gene transcription, and pulsatile GH secretion from anterior pituitary cells

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Further progression of NASH can lead to the development of liver fibrosis in patients

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178,179 Additionally, cAMP can activate Rap1 through EPAC (Exchange Protein directly Activated by cAMP), 180,181,182 which is involved in regulating insulin secretion